A decade with juvenile hormone receptor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00542422" target="_blank" >RIV/60077344:_____/21:00542422 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0065280621000011?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0065280621000011?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.aiip.2021.03.001" target="_blank" >10.1016/bs.aiip.2021.03.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A decade with juvenile hormone receptor

Popis výsledku v původním jazyce

Juvenile hormone (JH) and ecdysteroids represent equally important nonpeptide signals governing insect reproduction and development. For a considerable time, understanding of JH action lagged behind ecdysteroid research. Arriving with a 20-year delay, the intracellular receptor for JH was finally identified as a ligand-activated bHLH-PAS transcription factor, originally named Methoprene-tolerant (Met), by virtue of the resistance Drosophila mutants exhibited to morphogenetic and lethal actions of JH and its mimic methoprene. Systemic RNAi in suitable insect models revealed the anticipated function of Met in preventing metamorphosis and promoting reproduction, thus providing the missing link to the chief roles of JH in insects. That, along with defining the JH-binding pocket and the JH-response DNA elements of Met, established the JH receptor (JHR) 10 years ago. After reviewing the functional attributes of the JHR, this chapter will focus on advances in the genetics, cell biology, and biochemistry of the JHR achieved during this past decade. Although hormone receptor function of bHLH-PAS transcription factors is unprecedented, the well-studied mammalian aryl hydrocarbon receptor (AhR) belonging to the same protein family affords functional parallels with the JHR. We can now begin to understand the mechanisms of JHR interaction with the chaperone Hsp90/83, nucleocytoplasmic transport and post-translational regulation by phosphorylation, dimerization with bHLH-PAS partner proteins, and activation by agonist ligands binding to the PAS-B domain. A section is dedicated to current efforts exploiting the JHR as a basis of chemical high-throughput screening, aimed at discovery of novel compounds for environmentally friendly control of insect pests and disease vectors.

Název v anglickém jazyce

A decade with juvenile hormone receptor

Popis výsledku anglicky

Juvenile hormone (JH) and ecdysteroids represent equally important nonpeptide signals governing insect reproduction and development. For a considerable time, understanding of JH action lagged behind ecdysteroid research. Arriving with a 20-year delay, the intracellular receptor for JH was finally identified as a ligand-activated bHLH-PAS transcription factor, originally named Methoprene-tolerant (Met), by virtue of the resistance Drosophila mutants exhibited to morphogenetic and lethal actions of JH and its mimic methoprene. Systemic RNAi in suitable insect models revealed the anticipated function of Met in preventing metamorphosis and promoting reproduction, thus providing the missing link to the chief roles of JH in insects. That, along with defining the JH-binding pocket and the JH-response DNA elements of Met, established the JH receptor (JHR) 10 years ago. After reviewing the functional attributes of the JHR, this chapter will focus on advances in the genetics, cell biology, and biochemistry of the JHR achieved during this past decade. Although hormone receptor function of bHLH-PAS transcription factors is unprecedented, the well-studied mammalian aryl hydrocarbon receptor (AhR) belonging to the same protein family affords functional parallels with the JHR. We can now begin to understand the mechanisms of JHR interaction with the chaperone Hsp90/83, nucleocytoplasmic transport and post-translational regulation by phosphorylation, dimerization with bHLH-PAS partner proteins, and activation by agonist ligands binding to the PAS-B domain. A section is dedicated to current efforts exploiting the JHR as a basis of chemical high-throughput screening, aimed at discovery of novel compounds for environmentally friendly control of insect pests and disease vectors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/GX20-05151X" target="_blank" >GX20-05151X: Nalezení chybějících genetických komponent a chemických regulátorů signalizace juvenilního hormonu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advances in Insect Physiology

ISSN

0065-2806

e-ISSN

2213-6800

Svazek periodika

60

Číslo periodika v rámci svazku

JULY 7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

49

Strana od-do

37-85

Kód UT WoS článku

000748736100003

EID výsledku v databázi Scopus

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