Agonist-dependent action of the juvenile hormone receptor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00587906" target="_blank" >RIV/60077344:_____/24:00587906 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/24:43908829

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2214574524000762/pdfft?md5=e947b21312d9e8992bac1a9dbad34e0d&pid=1-s2.0-S2214574524000762-main.pdf" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2214574524000762/pdfft?md5=e947b21312d9e8992bac1a9dbad34e0d&pid=1-s2.0-S2214574524000762-main.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cois.2024.101234" target="_blank" >10.1016/j.cois.2024.101234</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Agonist-dependent action of the juvenile hormone receptor

Popis výsledku v původním jazyce

Juvenile hormone (JH) signaling is effected at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal to understand how these localized changes stimulate assembly of the active JHR complex, and thus fully grasp the mechanism of JHR signaling.

Název v anglickém jazyce

Agonist-dependent action of the juvenile hormone receptor

Popis výsledku anglicky

Juvenile hormone (JH) signaling is effected at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal to understand how these localized changes stimulate assembly of the active JHR complex, and thus fully grasp the mechanism of JHR signaling.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/GX20-05151X" target="_blank" >GX20-05151X: Nalezení chybějících genetických komponent a chemických regulátorů signalizace juvenilního hormonu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Insect Science

ISSN

2214-5745

e-ISSN

2214-5753

Svazek periodika

65

Číslo periodika v rámci svazku

OCT 2024

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

101234

Kód UT WoS článku

001278895400001

EID výsledku v databázi Scopus

2-s2.0-85199155777