Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00555307" target="_blank" >RIV/60077344:_____/21:00555307 - isvavai.cz</a>
Výsledek na webu
<a href="https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095091093095091424170" target="_blank" >https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095091093095091424170</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis
Popis výsledku v původním jazyce
Formation of dormant Mycobacterium tuberculosis (Mtb) cells is responsible for the phenomenon of latent tuberculosis. Serodiagnosis is an effective method for early detection of pathogen for many infection diseases. However, this method demonstrates low effectiveness for TB detection that could be due to incorrect antigens selected. We suggest to study the expression of protein antigens in dormant state of Mtb in vitro (5 mo old cells) obtained under gradual medium acidification which may reflect the real situation for the pathogen in case of latent TB. Analysis of the proteomic profile of active and dormant Mtb was carried out by LCMS/MS.
Název v anglickém jazyce
Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis
Popis výsledku anglicky
Formation of dormant Mycobacterium tuberculosis (Mtb) cells is responsible for the phenomenon of latent tuberculosis. Serodiagnosis is an effective method for early detection of pathogen for many infection diseases. However, this method demonstrates low effectiveness for TB detection that could be due to incorrect antigens selected. We suggest to study the expression of protein antigens in dormant state of Mtb in vitro (5 mo old cells) obtained under gradual medium acidification which may reflect the real situation for the pathogen in case of latent TB. Analysis of the proteomic profile of active and dormant Mtb was carried out by LCMS/MS.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů