Effect of population size and selection on Toll-like receptor diversity in populations of Galapagos mockingbirds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00567728" target="_blank" >RIV/60077344:_____/23:00567728 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10462156 RIV/60076658:12310/23:43906407

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jeb.14121" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jeb.14121</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jeb.14121" target="_blank" >10.1111/jeb.14121</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of population size and selection on Toll-like receptor diversity in populations of Galapagos mockingbirds

Popis výsledku v původním jazyce

The interactions of evolutionary forces are difficult to analyse in free-living populations. However, when properly understood, they provide valuable insights into evolutionary biology and conservation genetics. This is particularly important for the interplay of genetic drift and natural selection in immune genes that confer resistance to disease. The Galapagos Islands are inhabited by four closely related species of mockingbirds (Mimus spp.). We used 12 different-sized populations of Galapagos mockingbirds and one population of their continental relative northern mockingbird (Mimus polyglottos) to study the effects of genetic drift on the molecular evolution of immune genes, the Toll-like receptors (TLRs: TLR1B, TLR4 and TLR15). We found that neutral genetic diversity was positively correlated with island size, indicating an important effect of genetic drift. However, for TLR1B and TLR4, there was little correlation between functional (e.g., protein) diversity and island size, and protein structural properties were largely conserved, indicating only a limited effect of genetic drift on molecular phenotype. By contrast, TLR15 was less conserved and even its putative functional polymorphism correlated with island size. The patterns observed for the three genes suggest that genetic drift does not necessarily dominate selection even in relatively small populations, but that the final outcome depends on the degree of selection constraint that is specific for each TLR locus.

Název v anglickém jazyce

Effect of population size and selection on Toll-like receptor diversity in populations of Galapagos mockingbirds

Popis výsledku anglicky

The interactions of evolutionary forces are difficult to analyse in free-living populations. However, when properly understood, they provide valuable insights into evolutionary biology and conservation genetics. This is particularly important for the interplay of genetic drift and natural selection in immune genes that confer resistance to disease. The Galapagos Islands are inhabited by four closely related species of mockingbirds (Mimus spp.). We used 12 different-sized populations of Galapagos mockingbirds and one population of their continental relative northern mockingbird (Mimus polyglottos) to study the effects of genetic drift on the molecular evolution of immune genes, the Toll-like receptors (TLRs: TLR1B, TLR4 and TLR15). We found that neutral genetic diversity was positively correlated with island size, indicating an important effect of genetic drift. However, for TLR1B and TLR4, there was little correlation between functional (e.g., protein) diversity and island size, and protein structural properties were largely conserved, indicating only a limited effect of genetic drift on molecular phenotype. By contrast, TLR15 was less conserved and even its putative functional polymorphism correlated with island size. The patterns observed for the three genes suggest that genetic drift does not necessarily dominate selection even in relatively small populations, but that the final outcome depends on the degree of selection constraint that is specific for each TLR locus.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/GJ19-20152Y" target="_blank" >GJ19-20152Y: Efekt složení mikrobioty na prozánětlivou imunitu a výskyt klinických symptomů u socioekonomicky významných papoušků</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Evolutionary Biology

ISSN

1010-061X

e-ISSN

1420-9101

Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

109-120

Kód UT WoS článku

000888871100001

EID výsledku v databázi Scopus

2-s2.0-85142252635