Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468811" target="_blank" >RIV/60077344:_____/16:00468811 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/16:43890846 RIV/46747885:24620/16:00000829

Výsledek na webu

<a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >http://dx.doi.org/10.1111/mec.13807</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >10.1111/mec.13807</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds

Popis výsledku v původním jazyce

The extracellular subunit of the major histocompatibility complex MHCII plays an important role in the recognition of pathogens and the initiation of the adaptive immune response of vertebrates. It is widely accepted that pathogen-mediated selection in combination with neutral micro-evolutionary forces (e.g. genetic drift) shape the diversity of MHCII, but it has proved difficult to determine the relative effects of these forces. We evaluated the effect of genetic drift and balancing selection on MHCII diversity in 12 small populations of Galapagos mockingbirds belonging to four different species, and one larger population of the Northern mockingbird from the continental USA. After genotyping MHCII loci by high-throughput sequencing, we applied a correlational approach to explore the relationships between MHCII diversity and population size by proxy of island size. As expected when drift predominates, we found a positive effect of population size on the number of MHCII alleles present in a population. However, the number of MHCII alleles per individual and number of supertypes were not correlated with population size. This discrepancy points to an interesting feature of MHCII diversity dynamics: some levels of diversity might be shaped by genetic drift while others are independent and possibly maintained by balancing selection.

Název v anglickém jazyce

Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds

Popis výsledku anglicky

The extracellular subunit of the major histocompatibility complex MHCII plays an important role in the recognition of pathogens and the initiation of the adaptive immune response of vertebrates. It is widely accepted that pathogen-mediated selection in combination with neutral micro-evolutionary forces (e.g. genetic drift) shape the diversity of MHCII, but it has proved difficult to determine the relative effects of these forces. We evaluated the effect of genetic drift and balancing selection on MHCII diversity in 12 small populations of Galapagos mockingbirds belonging to four different species, and one larger population of the Northern mockingbird from the continental USA. After genotyping MHCII loci by high-throughput sequencing, we applied a correlational approach to explore the relationships between MHCII diversity and population size by proxy of island size. As expected when drift predominates, we found a positive effect of population size on the number of MHCII alleles present in a population. However, the number of MHCII alleles per individual and number of supertypes were not correlated with population size. This discrepancy points to an interesting feature of MHCII diversity dynamics: some levels of diversity might be shaped by genetic drift while others are independent and possibly maintained by balancing selection.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Ecology

ISSN

0962-1083

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

4757-4772

Kód UT WoS článku

000384810000006

EID výsledku v databázi Scopus

2-s2.0-84988959590