Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00570206" target="_blank" >RIV/60077344:_____/23:00570206 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0010854523000139?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010854523000139?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2023.215024" target="_blank" >10.1016/j.ccr.2023.215024</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

Popis výsledku v původním jazyce

Ferroptosis is a type of iron-mediated cell death merging cell metabolism, redox status, and human dis-ease. Reactive oxygen species (ROS) are formed after exposure to xenobiotics and normal metabolism, depending on their level, ROS can serve as intracellular redox messengers and regulators of cell fate, while excessive ROS amounts cause cellular oxidative changes, suppress protein activity, and trigger cell death. At the intracellular level, several redox mechanisms, such as the pyridine nucleotide redox systems involving thioredoxin and glutathione, are connected with ROS signaling and therefore contribute to cell status and function. Living in polluted conditions with an increased presence of fossil fuels, negatively affects human health and makes humans vulnerable to debilitating problems such as cancer and infec-tious diseases. The present understanding of ferroptosis in toxicity-mediated environmental exposures remains incomplete, and the underlying basis for the chemical stressors that trigger ferroptosis remains unclear. This review summarized the effects of environmental chemical exposure on cellular redox sig-naling, ferroptosis, and cell death providing critical information to stop the impact of ferroptosis on human health. (c) 2023 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

Popis výsledku anglicky

Ferroptosis is a type of iron-mediated cell death merging cell metabolism, redox status, and human dis-ease. Reactive oxygen species (ROS) are formed after exposure to xenobiotics and normal metabolism, depending on their level, ROS can serve as intracellular redox messengers and regulators of cell fate, while excessive ROS amounts cause cellular oxidative changes, suppress protein activity, and trigger cell death. At the intracellular level, several redox mechanisms, such as the pyridine nucleotide redox systems involving thioredoxin and glutathione, are connected with ROS signaling and therefore contribute to cell status and function. Living in polluted conditions with an increased presence of fossil fuels, negatively affects human health and makes humans vulnerable to debilitating problems such as cancer and infec-tious diseases. The present understanding of ferroptosis in toxicity-mediated environmental exposures remains incomplete, and the underlying basis for the chemical stressors that trigger ferroptosis remains unclear. This review summarized the effects of environmental chemical exposure on cellular redox sig-naling, ferroptosis, and cell death providing critical information to stop the impact of ferroptosis on human health. (c) 2023 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Coordination Chemistry Reviews

ISSN

0010-8545

e-ISSN

1873-3840

Svazek periodika

480

Číslo periodika v rámci svazku

JAN

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

215024

Kód UT WoS článku

000931547800001

EID výsledku v databázi Scopus

2-s2.0-85147110243