Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00582961" target="_blank" >RIV/60077344:_____/23:00582961 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/23:00132674 RIV/62156489:43210/23:43924459 RIV/00027162:_____/23:N0000221

Výsledek na webu

<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303585" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303585</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/slct.202303585" target="_blank" >10.1002/slct.202303585</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues

Popis výsledku v původním jazyce

Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2 'substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2 '-Anhydrouridine (2) with various nucleophiles to make several 2'-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2'-substituted L-nucleosides for numerous applications.

Název v anglickém jazyce

Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues

Popis výsledku anglicky

Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2 'substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2 '-Anhydrouridine (2) with various nucleophiles to make several 2'-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2'-substituted L-nucleosides for numerous applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistrySelect

ISSN

2365-6549

e-ISSN

2365-6549

Svazek periodika

8

Číslo periodika v rámci svazku

48

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

e202303585

Kód UT WoS článku

001128722500001

EID výsledku v databázi Scopus

2-s2.0-85180209542