Characterization and biological applications of CaCO3@Co0.5Zn0.5Fe2O4 nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00616582" target="_blank" >RIV/60077344:_____/24:00616582 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s00339-024-07367-0" target="_blank" >https://doi.org/10.1007/s00339-024-07367-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00339-024-07367-0" target="_blank" >10.1007/s00339-024-07367-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization and biological applications of CaCO3@Co0.5Zn0.5Fe2O4 nanoparticles

Popis výsledku v původním jazyce

CaCO3 coating was applied to the surface of Co0.5Zn0.5Fe2O4 (CZF) nanoparticles by chemical co-precipitation method. CaCO3-coated CZF(CC@CZF) and bare CZF nanoparticles have been characterized by spectroscopy and microscopy techniques. XRD patterns indicate the pure cubic spinel structure of CZF nanoparticles and the growth of CaCO3 layer on the nanoparticle's surface. The spherical shape and the size distribution of the nanoparticles were assessed to be similar to 30 nm before coating and similar to 60 nm after surface functionalization and confirmed by the FESEM microscopy technique. The magnetic characteristics of samples were investigated using the vibrating sample magnetometer technique, which revealed a drop in saturation magnetization from 45 to 32 emu/g. So, coated nanoparticles performed effectively as drug transporters under both normal and magnetic field circumstances. Hydrodynamic diameters of CZF nanoparticles are similar to 726 nm and decrease to similar to 370 nm due to the surface functionalization and cause reducing particle aggregation. An MTT test was used to assess the dose-dependent cellular cytotoxicity and viability of normal human skin cells (HSF 1184), which revealed that CC@CZF nanoparticles are less harmful than bare nanoparticles.

Název v anglickém jazyce

Characterization and biological applications of CaCO3@Co0.5Zn0.5Fe2O4 nanoparticles

Popis výsledku anglicky

CaCO3 coating was applied to the surface of Co0.5Zn0.5Fe2O4 (CZF) nanoparticles by chemical co-precipitation method. CaCO3-coated CZF(CC@CZF) and bare CZF nanoparticles have been characterized by spectroscopy and microscopy techniques. XRD patterns indicate the pure cubic spinel structure of CZF nanoparticles and the growth of CaCO3 layer on the nanoparticle's surface. The spherical shape and the size distribution of the nanoparticles were assessed to be similar to 30 nm before coating and similar to 60 nm after surface functionalization and confirmed by the FESEM microscopy technique. The magnetic characteristics of samples were investigated using the vibrating sample magnetometer technique, which revealed a drop in saturation magnetization from 45 to 32 emu/g. So, coated nanoparticles performed effectively as drug transporters under both normal and magnetic field circumstances. Hydrodynamic diameters of CZF nanoparticles are similar to 726 nm and decrease to similar to 370 nm due to the surface functionalization and cause reducing particle aggregation. An MTT test was used to assess the dose-dependent cellular cytotoxicity and viability of normal human skin cells (HSF 1184), which revealed that CC@CZF nanoparticles are less harmful than bare nanoparticles.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10102 - Applied mathematics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Physics A - Materials Science & Processing

ISSN

0947-8396

e-ISSN

1432-0630

Svazek periodika

130

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

215

Kód UT WoS článku

001176062900003

EID výsledku v databázi Scopus

2-s2.0-85186759618