Magnetic nanoparticles of Ga-substituted ε-Fe2O3 for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00532459" target="_blank" >RIV/68378271:_____/20:00532459 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/jbm.a.36926" target="_blank" >https://doi.org/10.1002/jbm.a.36926</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.36926" target="_blank" >10.1002/jbm.a.36926</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic nanoparticles of Ga-substituted ε-Fe2O3 for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Popis výsledku v původním jazyce

Magnetic nanoparticles of epsilon-Fe1.76Ga0.24O3 with the volume-weighted mean size of 17 nm were prepared by thermal treatment of a mesoporous silica template impregnated with metal nitrates and were coated with silica shell of four different thicknesses in the range 6-24 nm. The bare particles exhibited higher magnetization than the undoped compound, 22.4 Am-2 kg-1 at 300 K, and were characterized by blocked state with the coercivity of 1.2 T at 300 K. The relaxometric study of the silica-coated samples at 0.47 T revealed promising properties for MRI, specifically, transverse relaxivity of 89-168 s-1mmol(f)-1L depending on the shell thickness was observed. We investigated the effects of the silica-coated nanoparticles on human A549 and MCF-7 cells. Cell viability, proliferation, cell cycle distribution, and the arrangement of actin cytoskeleton were assessed, as well as formation and maturation of focal adhesions.

Název v anglickém jazyce

Magnetic nanoparticles of Ga-substituted ε-Fe2O3 for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Popis výsledku anglicky

Magnetic nanoparticles of epsilon-Fe1.76Ga0.24O3 with the volume-weighted mean size of 17 nm were prepared by thermal treatment of a mesoporous silica template impregnated with metal nitrates and were coated with silica shell of four different thicknesses in the range 6-24 nm. The bare particles exhibited higher magnetization than the undoped compound, 22.4 Am-2 kg-1 at 300 K, and were characterized by blocked state with the coercivity of 1.2 T at 300 K. The relaxometric study of the silica-coated samples at 0.47 T revealed promising properties for MRI, specifically, transverse relaxivity of 89-168 s-1mmol(f)-1L depending on the shell thickness was observed. We investigated the effects of the silica-coated nanoparticles on human A549 and MCF-7 cells. Cell viability, proliferation, cell cycle distribution, and the arrangement of actin cytoskeleton were assessed, as well as formation and maturation of focal adhesions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Materials Research. Part A

ISSN

1549-3296

e-ISSN

—

Svazek periodika

108

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

1563-1578

Kód UT WoS článku

000521206500001

EID výsledku v databázi Scopus

2-s2.0-85082193141