T-2- and T-1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27710%2F21%3A10247537" target="_blank" >RIV/61989100:27710/21:10247537 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s12039-021-01904-7" target="_blank" >https://link.springer.com/article/10.1007/s12039-021-01904-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12039-021-01904-7" target="_blank" >10.1007/s12039-021-01904-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

T-2- and T-1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes

Popis výsledku v původním jazyce

The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8 +/- 2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1 +/- 14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM(-1) s(-1), respectively) at 1.5 T and 25 degrees C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.

Název v anglickém jazyce

T-2- and T-1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes

Popis výsledku anglicky

The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8 +/- 2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1 +/- 14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM(-1) s(-1), respectively) at 1.5 T and 25 degrees C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20400 - Chemical engineering

Projekt

<a href="/cs/project/EF16_019%2F0000853" target="_blank" >EF16_019/0000853: Institut environmentálních technologií - excelentní výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chemical Sciences

ISSN

0974-3626

e-ISSN

—

Svazek periodika

133

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000642407200001

EID výsledku v databázi Scopus

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