SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00618897" target="_blank" >RIV/60077344:_____/25:00618897 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12220/25:43909779 RIV/60076658:12310/25:43909779

Výsledek na webu

<a href="https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5L2VsaWZlLTEwNTAzOS12MS5wZGY_Y2Fub25pY2FsVXJpPWh0dHBzOi8vZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5/elife-105039-v1.pdf?_hash=X63s%2F0uvn60DRBU1NWVUkrKbc7qba2FGTCWiX4bLeAI%3D" target="_blank" >https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5L2VsaWZlLTEwNTAzOS12MS5wZGY_Y2Fub25pY2FsVXJpPWh0dHBzOi8vZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5/elife-105039-v1.pdf?_hash=X63s%2F0uvn60DRBU1NWVUkrKbc7qba2FGTCWiX4bLeAI%3D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.105039.3" target="_blank" >10.7554/eLife.105039.3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Popis výsledku v původním jazyce

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group donor for most methylations in the cell and is synthesized from methionine and ATP. After methylation, SAM is converted to S-adenosylhomocysteine, which is further metabolized to adenosine and homocysteine. Here, we show that the SAM transmethylation pathway is up-regulated during immune cell activation and that the adenosine produced by this pathway in immune cells acts as a systemic signal to delay Drosophila larval development and ensure sufficient nutrient supply to the immune system. We further show that the up-regulation of the SAM transmethylation pathway and the efficiency of the immune response also depend on the recycling of adenosine back to ATP by adenosine kinase and adenylate kinase. We therefore hypothesize that adenosine may act as a sensitive sensor of the balance between cell activity, represented by the sum of methylation events in the cell, and nutrient supply. If the supply of nutrients is insufficient for a given activity, adenosine may not be effectively recycled back into ATP and may be pushed out of the cell to serve as a signal to demand more nutrients.

Název v anglickém jazyce

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Popis výsledku anglicky

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group donor for most methylations in the cell and is synthesized from methionine and ATP. After methylation, SAM is converted to S-adenosylhomocysteine, which is further metabolized to adenosine and homocysteine. Here, we show that the SAM transmethylation pathway is up-regulated during immune cell activation and that the adenosine produced by this pathway in immune cells acts as a systemic signal to delay Drosophila larval development and ensure sufficient nutrient supply to the immune system. We further show that the up-regulation of the SAM transmethylation pathway and the efficiency of the immune response also depend on the recycling of adenosine back to ATP by adenosine kinase and adenylate kinase. We therefore hypothesize that adenosine may act as a sensitive sensor of the balance between cell activity, represented by the sum of methylation events in the cell, and nutrient supply. If the supply of nutrients is insufficient for a given activity, adenosine may not be effectively recycled back into ATP and may be pushed out of the cell to serve as a signal to demand more nutrients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

eLife

ISSN

2050-084X

e-ISSN

2050-084X

Svazek periodika

13

Číslo periodika v rámci svazku

APR 07

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

39

Strana od-do

RP105039

Kód UT WoS článku

001462287600001

EID výsledku v databázi Scopus

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