A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F03%3A00000902" target="_blank" >RIV/60162694:G16__/03:00000902 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G38__/03:00000902

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods

Popis výsledku v původním jazyce

The efficacy of a new bispyridinium oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, called K048, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. The new oxime K048 was found to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than pralidoxime (in the case of VX, tabun and cyclosarin), obidoxime (in the case of cyclosarin and tabun) and HI-6 (in the case of tabun) but it did not reach the efficacy of currently used oximes in the case of the inhibition of acetylcholinesterase by sarin. Thus, the oxime K048 seems to be relatively efficaciousbroad spectrum acetylcholinesterase reactivator and, therefore, it could be useful for the treatment of nerve agent-exposed people if information about detection of type of nerve agent is absent.

Název v anglickém jazyce

A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods

Popis výsledku anglicky

The efficacy of a new bispyridinium oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, called K048, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. The new oxime K048 was found to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than pralidoxime (in the case of VX, tabun and cyclosarin), obidoxime (in the case of cyclosarin and tabun) and HI-6 (in the case of tabun) but it did not reach the efficacy of currently used oximes in the case of the inhibition of acetylcholinesterase by sarin. Thus, the oxime K048 seems to be relatively efficaciousbroad spectrum acetylcholinesterase reactivator and, therefore, it could be useful for the treatment of nerve agent-exposed people if information about detection of type of nerve agent is absent.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Enzyme Inhibition and Medicinal Chemistry

ISSN

8755-5093

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

529-535

Kód UT WoS článku

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EID výsledku v databázi Scopus

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