In vitro reaktivace acetylcholinesterazy užitím oximu K027

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001078" target="_blank" >RIV/60162694:G38__/04:00001078 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In vitro reactivation of acetylcholinesterase using the oxime K027

Popis výsledku v původním jazyce

The ability of new bisquaternary oxime - K027 [1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide] to reactivate the enzyme acetylcholinesterase inhibited by nerve agents is evaluated in this study. Tabun, sarin and VX agent wereused as nerve agents. Its reactivation potency was compared to currently used acetylcholinesterase reactivators such as pralidoxime, obidoxime and HI-6. Our new oxime K027 seems to be a good reactivator of organophosphates-inhibited AChE. Its reactivation potency is lower compared to the other oximes in the case of the reactivation of sarin-inhibited acetylcholinesterase, but it is sufficient to significantly increase the activity of sarin-inhibited acetylcholinesterase. On the other hand, its reactivation ability is comparable to obidoxime in the case of reactivation of VX- and tabun-inhibited acetycholinesterase. In addition, its reactivation potency of tabun-inhibited acetylcholinesterase is higher than a reactivation potency of the

Název v anglickém jazyce

In vitro reactivation of acetylcholinesterase using the oxime K027

Popis výsledku anglicky

The ability of new bisquaternary oxime - K027 [1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide] to reactivate the enzyme acetylcholinesterase inhibited by nerve agents is evaluated in this study. Tabun, sarin and VX agent wereused as nerve agents. Its reactivation potency was compared to currently used acetylcholinesterase reactivators such as pralidoxime, obidoxime and HI-6. Our new oxime K027 seems to be a good reactivator of organophosphates-inhibited AChE. Its reactivation potency is lower compared to the other oximes in the case of the reactivation of sarin-inhibited acetylcholinesterase, but it is sufficient to significantly increase the activity of sarin-inhibited acetylcholinesterase. On the other hand, its reactivation ability is comparable to obidoxime in the case of reactivation of VX- and tabun-inhibited acetycholinesterase. In addition, its reactivation potency of tabun-inhibited acetylcholinesterase is higher than a reactivation potency of the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary and Human Toxicology

ISSN

0145-6296

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

15-18

Kód UT WoS článku

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EID výsledku v databázi Scopus

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