Ruská VX: Inhibice a reaktivace acetylcholinesterazy a srovnávání s VX

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001492" target="_blank" >RIV/60162694:G44__/06:00001492 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Russian VX: Inhibition and reactivation of acetylcholinesterase and its comparison with VX-agent

Popis výsledku v původním jazyce

Organophosphorus compounds such as nerve agents inhibit, practically irreversible, cholinesterases (ChEs) by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent (NA) intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivator (HI-6, obidoxime, pralidoxime), which is from the chemical view a derivative from the group of pyridinium or bispyridinium aldoximes (commonly called #oxime#). Oximes counteract acetylcholine increase, resulting from AChE inhibition. These compounds are, in the conditions of human body environment, powerful nucleophiles and are able to break down the bond between AChE andNA molecule. This process leads to renew of enzyme functionality - to its reactivation. The usability of oxime in reactivation process depends on its chemical structure and on the NA agent whereby AChE was inhibited. Due to this fact, se

Název v anglickém jazyce

Russian VX: Inhibition and reactivation of acetylcholinesterase and its comparison with VX-agent

Popis výsledku anglicky

Organophosphorus compounds such as nerve agents inhibit, practically irreversible, cholinesterases (ChEs) by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent (NA) intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivator (HI-6, obidoxime, pralidoxime), which is from the chemical view a derivative from the group of pyridinium or bispyridinium aldoximes (commonly called #oxime#). Oximes counteract acetylcholine increase, resulting from AChE inhibition. These compounds are, in the conditions of human body environment, powerful nucleophiles and are able to break down the bond between AChE andNA molecule. This process leads to renew of enzyme functionality - to its reactivation. The usability of oxime in reactivation process depends on its chemical structure and on the NA agent whereby AChE was inhibited. Due to this fact, se

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Basic and Clinical Pharmacology and Toxicology

ISSN

1742-7835

e-ISSN

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Svazek periodika

98

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

389-394

Kód UT WoS článku

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EID výsledku v databázi Scopus

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