Prophylaxis against nerve agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002123" target="_blank" >RIV/60162694:G44__/09:00002123 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prophylaxis against nerve agents

Popis výsledku v původním jazyce

Prophylaxis against nerve agent intoxication is based on various approaches: keeping acetylcholinesterase intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. The use of pyridostigmine alone or pyridostigmine with benactyzine and trihehyphenidyle (PANPAL) is typical example. Detoxification realised by administration of the enzymes splitting the organophosphate or evaluating specific enzymes (cholinesterases) is another possibility (stoichiometric and catalytic scavengers). Equine butyrylcholinesterase is an example of stoichiometric scavenger. The antidotes currently used for the treatment of organophosphate poisoning including reactivators are to be tested as prophylactics. As a result of this research, prophylacticantidote TRANSANT (transdermal patch containing HI-6) was developed as the prophylactic mean and introduced into the Czech Armed Forces.

Název v anglickém jazyce

Prophylaxis against nerve agents

Popis výsledku anglicky

Prophylaxis against nerve agent intoxication is based on various approaches: keeping acetylcholinesterase intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. The use of pyridostigmine alone or pyridostigmine with benactyzine and trihehyphenidyle (PANPAL) is typical example. Detoxification realised by administration of the enzymes splitting the organophosphate or evaluating specific enzymes (cholinesterases) is another possibility (stoichiometric and catalytic scavengers). Equine butyrylcholinesterase is an example of stoichiometric scavenger. The antidotes currently used for the treatment of organophosphate poisoning including reactivators are to be tested as prophylactics. As a result of this research, prophylacticantidote TRANSANT (transdermal patch containing HI-6) was developed as the prophylactic mean and introduced into the Czech Armed Forces.

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Central and peripheral nervous system: effects of highly toxic organophosphates and their antidotes

ISBN

978-81-308-0331-9

Počet stran výsledku

12

Strana od-do

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Počet stran knihy

151

Název nakladatele

Research Signpost

Místo vydání

Kerala

Kód UT WoS kapitoly

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