Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002369" target="_blank" >RIV/60162694:G44__/09:00002369 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents

Popis výsledku v původním jazyce

The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed.

Název v anglickém jazyce

Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents

Popis výsledku anglicky

The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed.

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OVUOFVZ200902" target="_blank" >OVUOFVZ200902: OTRAVA - Výzkum nových typů antidot otrav nervově paralytickými látkami na bázi scavengerů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Central and peripheral nervous system: effects of highly toxic organophosphates and their antidotes

ISBN

978-81-308-0331-9

Počet stran výsledku

9

Strana od-do

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Počet stran knihy

151

Název nakladatele

Research Signpost

Místo vydání

Kerala

Kód UT WoS kapitoly

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