Pharmacological prophylaxis against nerve agent poisoning: experimental studies and practical implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50004537" target="_blank" >RIV/62690094:18470/15:50004537 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10320663

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X" target="_blank" >10.1016/B978-0-12-800159-2.00066-X</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacological prophylaxis against nerve agent poisoning: experimental studies and practical implications

Popis výsledku v původním jazyce

Prophylaxis against intoxication with organophosphate (OP) nerve agents is based on various approaches. Protection of acetylcholinesterase (AChE), the target enzyme for toxic action of OP nerve agents, is a basic requirement for effective prophylaxis. This can be achieved by using reversible AChE inhibitors, preferably carbamates (CMs). AChE inhibited by CMs is resistant to the action of an OP nerve agent for a transient period. After spontaneous recovery of the activity, normal AChE serves as a sourceof the active enzyme. Detoxification is carried out by the administration of enzymes hydrolyzing the OPs or evaluating specific enzymes (cholinesterases). The OP nerve agent is bound to the exogenously administered enzyme, and thus the OP level in the organism is decreased ("scavenger" effect). The administration of enzymes such as AChE and butyrylcholinesterase (BuChE) as scavengers seems to be very promising, as the enzyme acts at the very beginning of the toxic action, and without int

Název v anglickém jazyce

Pharmacological prophylaxis against nerve agent poisoning: experimental studies and practical implications

Popis výsledku anglicky

Prophylaxis against intoxication with organophosphate (OP) nerve agents is based on various approaches. Protection of acetylcholinesterase (AChE), the target enzyme for toxic action of OP nerve agents, is a basic requirement for effective prophylaxis. This can be achieved by using reversible AChE inhibitors, preferably carbamates (CMs). AChE inhibited by CMs is resistant to the action of an OP nerve agent for a transient period. After spontaneous recovery of the activity, normal AChE serves as a sourceof the active enzyme. Detoxification is carried out by the administration of enzymes hydrolyzing the OPs or evaluating specific enzymes (cholinesterases). The OP nerve agent is bound to the exogenously administered enzyme, and thus the OP level in the organism is decreased ("scavenger" effect). The administration of enzymes such as AChE and butyrylcholinesterase (BuChE) as scavengers seems to be very promising, as the enzyme acts at the very beginning of the toxic action, and without int

Druh

C - Kapitola v odborné knize

CEP obor

KA - Vojenství

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of toxicology of chemical warfare agents

ISBN

978-0-12-800159-2

Počet stran výsledku

9

Strana od-do

979-987

Počet stran knihy

1184

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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