Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50004539" target="_blank" >RIV/62690094:18470/15:50004539 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/15:43875536 RIV/00179906:_____/15:10320677

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8" target="_blank" >10.1016/B978-0-12-800159-2.00065-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Popis výsledku v původním jazyce

Nerve agents are organophosphorus compounds influencing cholinergic nerve transmission via inhibition of acetylcholinesterase (AChE; EC 3.1.1.7). The symptoms of intoxication include nicotinic, muscarinic, and central symptoms. Cholinesterases (ChEs; AChE and butyrylcholinesterase [BChE] EC 3.1.1.8) are characterized as the main enzymes involved in the toxic effect of these compounds including molecular forms. The activity of both enzymes is influenced by inhibitors and other factors such as their pathological states. The determination of ChEs is a key diagnostic tool in the diagnosis of poisoning with ChE inhibitors (OPs, nerve agents, and carbamates). For nerve agent intoxication, AChE in red blood cells is more diagnostically important than BChE activity in plasma. There are several methods for ChE determination; however, the most frequent is the Ellman's method and its modifications based on the hydrolysis of thiocholine esters and after detection of the free SH-group of the releas

Název v anglickém jazyce

Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Popis výsledku anglicky

Nerve agents are organophosphorus compounds influencing cholinergic nerve transmission via inhibition of acetylcholinesterase (AChE; EC 3.1.1.7). The symptoms of intoxication include nicotinic, muscarinic, and central symptoms. Cholinesterases (ChEs; AChE and butyrylcholinesterase [BChE] EC 3.1.1.8) are characterized as the main enzymes involved in the toxic effect of these compounds including molecular forms. The activity of both enzymes is influenced by inhibitors and other factors such as their pathological states. The determination of ChEs is a key diagnostic tool in the diagnosis of poisoning with ChE inhibitors (OPs, nerve agents, and carbamates). For nerve agent intoxication, AChE in red blood cells is more diagnostically important than BChE activity in plasma. There are several methods for ChE determination; however, the most frequent is the Ellman's method and its modifications based on the hydrolysis of thiocholine esters and after detection of the free SH-group of the releas

Druh

C - Kapitola v odborné knize

CEP obor

KA - Vojenství

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of toxicology of chemical warfare agents

ISBN

978-0-12-800159-2

Počet stran výsledku

10

Strana od-do

967-976

Počet stran knihy

1184

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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