Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002132" target="_blank" >RIV/60162694:G44__/09:00002132 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

Popis výsledku v původním jazyce

Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 ?g/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and allanimals died.

Název v anglickém jazyce

Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

Popis výsledku anglicky

Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 ?g/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and allanimals died.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-0287

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000267953800003

EID výsledku v databázi Scopus

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