Bioanalytical tools for the discovery of eukaryotic glycoproteins applied to the analysis of bacterial glycoproteins

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bioanalytical tools for the discovery of eukaryotic glycoproteins applied to the analysis of bacterial glycoproteins

Popis výsledku v původním jazyce

The commonly-accepted theory that prokaryotes lack the ability to glycosylate their proteins has been disproved recently. The field of bacterial glycoprotein research is no longer considered novel owing to the rapid progress in analytical technologies and genome sequencing that has been made in the last few years. Enhanced interest in glycoprotein discovery in bacteria can be explained by a proven correlation between the presence of glycosylation and bacterial pathogenicity. Eukaryotic and prokaryotic organisms's features share certain similarities. However, with respect to inherent differences between these two distinct domains of life, the use of bioanalytical tools for glycoprotein analysis in eukaryotic systems often needs modification to be applied successfully to bacteria. In this article, we draw attention to the differences between eukaryotic and prokaryotic glycoproteins. We also focus on the main bottlenecks that may be encountered in the search for glycosylation in concrete

Název v anglickém jazyce

Bioanalytical tools for the discovery of eukaryotic glycoproteins applied to the analysis of bacterial glycoproteins

Popis výsledku anglicky

The commonly-accepted theory that prokaryotes lack the ability to glycosylate their proteins has been disproved recently. The field of bacterial glycoprotein research is no longer considered novel owing to the rapid progress in analytical technologies and genome sequencing that has been made in the last few years. Enhanced interest in glycoprotein discovery in bacteria can be explained by a proven correlation between the presence of glycosylation and bacterial pathogenicity. Eukaryotic and prokaryotic organisms's features share certain similarities. However, with respect to inherent differences between these two distinct domains of life, the use of bioanalytical tools for glycoprotein analysis in eukaryotic systems often needs modification to be applied successfully to bacteria. In this article, we draw attention to the differences between eukaryotic and prokaryotic glycoproteins. We also focus on the main bottlenecks that may be encountered in the search for glycosylation in concrete

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Expert Review of Proteomics

ISSN

1478-9450

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000263761400008

EID výsledku v databázi Scopus

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