Crohn's disease activity versus extent of DNA damage/repair and variability in the rage gene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002362" target="_blank" >RIV/60162694:G44__/10:00002362 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/10:00040533

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Crohn's disease activity versus extent of DNA damage/repair and variability in the rage gene

Popis výsledku v původním jazyce

The aim of the study was to investigate the relationships between the extent of oxidative stress and DNA damage/repair, disease severity, and selected genetic variants in the RAGE gene in Crohn's disease (CD) patients. The study comprised a total of 46 subjects with CD and 99 control subjects. Disease activity was characterised by the Crohn's Disease Activity Index (CDAI) and paediatric CDAI (PCDAI) and complications requiring surgery (abscess, fistula or stenosis). Selected markers of oxidative stress(superoxide dismutase (Ery-SOD), glutathione peroxidase (WB-GPx), total plasma antioxidant capacity (P-tAOC), reduced glutathione (Ery-GSH) and malondialdehyde (P-MDA)), DNA damage (DNA single-strand breaks), and repair capacity detected (DNArc) by Cometassay were ascertained. Four SNPs in the RAGE gene were detected by PCR. A significant correlation between CD duration and DNArc was identified in adult patients (r = 0.44, P = 0.039), and adult CD subjects had significantly higher Ery-S

Název v anglickém jazyce

Crohn's disease activity versus extent of DNA damage/repair and variability in the rage gene

Popis výsledku anglicky

The aim of the study was to investigate the relationships between the extent of oxidative stress and DNA damage/repair, disease severity, and selected genetic variants in the RAGE gene in Crohn's disease (CD) patients. The study comprised a total of 46 subjects with CD and 99 control subjects. Disease activity was characterised by the Crohn's Disease Activity Index (CDAI) and paediatric CDAI (PCDAI) and complications requiring surgery (abscess, fistula or stenosis). Selected markers of oxidative stress(superoxide dismutase (Ery-SOD), glutathione peroxidase (WB-GPx), total plasma antioxidant capacity (P-tAOC), reduced glutathione (Ery-GSH) and malondialdehyde (P-MDA)), DNA damage (DNA single-strand breaks), and repair capacity detected (DNArc) by Cometassay were ascertained. Four SNPs in the RAGE gene were detected by PCR. A significant correlation between CD duration and DNArc was identified in adult patients (r = 0.44, P = 0.039), and adult CD subjects had significantly higher Ery-S

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/KJB501620601" target="_blank" >KJB501620601: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scripta medica Facultatis medicae Universitatis Brunensis Masarykianae

ISSN

1211-3395

e-ISSN

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Svazek periodika

83

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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