HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002514" target="_blank" >RIV/60162694:G44__/11:00002514 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/11:43870283

Výsledek na webu

<a href="http://www.academicjournals.org/ajpp/PDF/pdf2011/Aug/Pohanka%20et%20al.pdf" target="_blank" >http://www.academicjournals.org/ajpp/PDF/pdf2011/Aug/Pohanka%20et%20al.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis

Popis výsledku v původním jazyce

The oxime reactivators, obidoxime and asoxime (HI-6) are suitable for antidotal treatment after exposure to nerve agents. Although they are considered for use in humans under emergency situations, complete clinical studies are lacking as there were no clinical trials. We examined obidoxime and HI-6 in laboratory rats intramuscularly exposed to 25% of the median lethal dose (210 and 780 mg/kg) of each oxime reactivator and sacrificed 40 min after exposure. Brain and liver ferric reducing antioxidant power, reduced glutathione (GSH), glutathione reductase, thiobarbituric acid reactive substances, acetylcholinesterase, caspase 3 and glutathione S-transferase were assessed using standard protocols. We found significant depletion of liver and brain low molecular weight antioxidants. On the other hand, the depletion was partially recovered by an increase in the GSH level. Obidoxime was implicated in alteration of apoptotic processes in brain. Overall effects of oxime reactivators are discuss

Název v anglickém jazyce

HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis

Popis výsledku anglicky

The oxime reactivators, obidoxime and asoxime (HI-6) are suitable for antidotal treatment after exposure to nerve agents. Although they are considered for use in humans under emergency situations, complete clinical studies are lacking as there were no clinical trials. We examined obidoxime and HI-6 in laboratory rats intramuscularly exposed to 25% of the median lethal dose (210 and 780 mg/kg) of each oxime reactivator and sacrificed 40 min after exposure. Brain and liver ferric reducing antioxidant power, reduced glutathione (GSH), glutathione reductase, thiobarbituric acid reactive substances, acetylcholinesterase, caspase 3 and glutathione S-transferase were assessed using standard protocols. We found significant depletion of liver and brain low molecular weight antioxidants. On the other hand, the depletion was partially recovered by an increase in the GSH level. Obidoxime was implicated in alteration of apoptotic processes in brain. Overall effects of oxime reactivators are discuss

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OVUOFVZ200905" target="_blank" >OVUOFVZ200905: MORČE - Působení nervově paralytických látek a reaktivátorů acetylcholinesterázy na morče</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

African Journal of Pharmacy and Pharmacology

ISSN

1996-0816

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NG - Nigérijská federativní republika

Počet stran výsledku

5

Strana od-do

1145-1149

Kód UT WoS článku

000295800500021

EID výsledku v databázi Scopus

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