Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874971" target="_blank" >RIV/60162694:G44__/13:43874971 - isvavai.cz</a>

Výsledek na webu

<a href="http://academicjournals.org/journal/AJPP/article-abstract/068711B26356" target="_blank" >http://academicjournals.org/journal/AJPP/article-abstract/068711B26356</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5897/AJPP12.438" target="_blank" >10.5897/AJPP12.438</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety

Popis výsledku v původním jazyce

Obidoxime and asoxime (HI-6) are considered to be the most important acetylcholinesterase (AChE) reactivators applicable for treatment of poisoning by nerve agents. Unfortunately, toxicology of the oximes is not well known. For this reason, we decided toinvestigate the pertinent adverse effects on guinea pigs which are close to humans in toxicological point of view. HI-6 and obidoxime were administered intramuscularly in 5% of the median lethal dose. The animals were sacrificed 15, 30, 60, 120, and 240min after exposure, and the brain, liver, spleen and kidneys were collected. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione S-transferase (GST) and glutathione reductase (GR) were measured. Resultsindicated that obidoxime acted on oxidative stress than HI-6. We found evidence of low molecular weight antioxidants depletion after obidoxime administration. On the other hand, TBARS assay showed significant decrease in brain and little

Název v anglickém jazyce

Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety

Popis výsledku anglicky

Obidoxime and asoxime (HI-6) are considered to be the most important acetylcholinesterase (AChE) reactivators applicable for treatment of poisoning by nerve agents. Unfortunately, toxicology of the oximes is not well known. For this reason, we decided toinvestigate the pertinent adverse effects on guinea pigs which are close to humans in toxicological point of view. HI-6 and obidoxime were administered intramuscularly in 5% of the median lethal dose. The animals were sacrificed 15, 30, 60, 120, and 240min after exposure, and the brain, liver, spleen and kidneys were collected. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione S-transferase (GST) and glutathione reductase (GR) were measured. Resultsindicated that obidoxime acted on oxidative stress than HI-6. We found evidence of low molecular weight antioxidants depletion after obidoxime administration. On the other hand, TBARS assay showed significant decrease in brain and little

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

African Journal of Pharmacy and Pharmacology

ISSN

1996-0816

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

NG - Nigérijská federativní republika

Počet stran výsledku

6

Strana od-do

2252-2257

Kód UT WoS článku

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EID výsledku v databázi Scopus

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