DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002563" target="_blank" >RIV/60162694:G44__/11:00002563 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1093/carcin/bgq213" target="_blank" >http://dx.doi.org/10.1093/carcin/bgq213</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes

Popis výsledku v původním jazyce

We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNAdamage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XR

Název v anglickém jazyce

DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes

Popis výsledku anglicky

We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNAdamage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XR

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

74-79

Kód UT WoS článku

000286303000012

EID výsledku v databázi Scopus

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