Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874619" target="_blank" >RIV/60162694:G44__/12:43874619 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3390/ijms13022219" target="_blank" >http://dx.doi.org/10.3390/ijms13022219</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms13022219" target="_blank" >10.3390/ijms13022219</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology

Popis výsledku v původním jazyce

Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiplecognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper.

Název v anglickém jazyce

Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology

Popis výsledku anglicky

Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiplecognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

2219-2238

Kód UT WoS článku

000300715700060

EID výsledku v databázi Scopus

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