Pharmacological influencing of the cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F21%3A00556844" target="_blank" >RIV/60162694:G44__/21:00556844 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/33208075/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33208075/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1389557520666201117111715" target="_blank" >10.2174/1389557520666201117111715</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacological influencing of the cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies

Popis výsledku v původním jazyce

The cholinergic anti-inflammatory pathway is a part of the parasympathetic nervous system and it can also be entitled as an anti-inflammatory reflex. It consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (AChE) terminating the neurotransmission. Stopping of inflammatory cytokines production is the major task for the cholinergic anti-inflammatory pathway. The cholinergic anti-inflammatory pathway can be stimulated or suppressed by agonizing or antagonizing alpha 7 nAChR or by inhibition of AChE. This review is focused on cholinergic anti-inflammatory pathway regulation by drugs. Compounds that inhibit cholinesterases (for instance, huperzine, rivastigmine, galantamine), and their impact on the cholinergic anti-inflammatory pathway are discussed here and a survey of actual literature is provided.

Název v anglickém jazyce

Pharmacological influencing of the cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies

Popis výsledku anglicky

The cholinergic anti-inflammatory pathway is a part of the parasympathetic nervous system and it can also be entitled as an anti-inflammatory reflex. It consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (AChE) terminating the neurotransmission. Stopping of inflammatory cytokines production is the major task for the cholinergic anti-inflammatory pathway. The cholinergic anti-inflammatory pathway can be stimulated or suppressed by agonizing or antagonizing alpha 7 nAChR or by inhibition of AChE. This review is focused on cholinergic anti-inflammatory pathway regulation by drugs. Compounds that inhibit cholinesterases (for instance, huperzine, rivastigmine, galantamine), and their impact on the cholinergic anti-inflammatory pathway are discussed here and a survey of actual literature is provided.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mini-Reviews in Medicinal Chemistry

ISSN

1389-5575

e-ISSN

1875-5607

Svazek periodika

21

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

10

Strana od-do

660-669

Kód UT WoS článku

000620347300001

EID výsledku v databázi Scopus

2-s2.0-85101239318