Cholinergic Anti-inflammatory Pathway and Stroke
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00067522" target="_blank" >RIV/65269705:_____/17:00067522 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/17:00095205
Výsledek na webu
<a href="http://dx.doi.org/10.2174/1567201814666170201150015" target="_blank" >http://dx.doi.org/10.2174/1567201814666170201150015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1567201814666170201150015" target="_blank" >10.2174/1567201814666170201150015</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cholinergic Anti-inflammatory Pathway and Stroke
Popis výsledku v původním jazyce
Background: Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Methods: Research articles related to cholinergic anti-inflammatory pathway (CHAIP) and stroke were reviewed. The first part of review describes the basic characteristics of inflammatory response after stroke, main components and function of CHAIP. The second part reviews studies focused on CHAIP as a therapeutic target for ischemic and hemorrhagic stroke. Both pharmacological stimulation of alpha 7 nAChR and vagus nerve stimulation after stroke are reviewed. Results: Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) are the main components of CHAIP. Conclusion: Targeting cholinergic anti-inflammatory pathway is a promising way of immunomodulation which attenuates inflammation in a complex manner without causing immunosuppression.
Název v anglickém jazyce
Cholinergic Anti-inflammatory Pathway and Stroke
Popis výsledku anglicky
Background: Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Methods: Research articles related to cholinergic anti-inflammatory pathway (CHAIP) and stroke were reviewed. The first part of review describes the basic characteristics of inflammatory response after stroke, main components and function of CHAIP. The second part reviews studies focused on CHAIP as a therapeutic target for ischemic and hemorrhagic stroke. Both pharmacological stimulation of alpha 7 nAChR and vagus nerve stimulation after stroke are reviewed. Results: Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) are the main components of CHAIP. Conclusion: Targeting cholinergic anti-inflammatory pathway is a promising way of immunomodulation which attenuates inflammation in a complex manner without causing immunosuppression.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
<a href="/cs/project/GP14-23773P" target="_blank" >GP14-23773P: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Drug Delivery
ISSN
1567-2018
e-ISSN
—
Svazek periodika
14
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
9
Strana od-do
449-457
Kód UT WoS článku
000405313200002
EID výsledku v databázi Scopus
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