Acetylcholinesterase inhibitors: a patent review (2008 - present)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874625" target="_blank" >RIV/60162694:G44__/12:43874625 - isvavai.cz</a>

Výsledek na webu

<a href="http://informahealthcare.com/doi/abs/10.1517/13543776.2012.701620" target="_blank" >http://informahealthcare.com/doi/abs/10.1517/13543776.2012.701620</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1517/13543776.2012.701620" target="_blank" >10.1517/13543776.2012.701620</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acetylcholinesterase inhibitors: a patent review (2008 - present)

Popis výsledku v původním jazyce

Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are present in the body in large amounts. AChE is an important part of the cholinergic nervous system taking place in the central and peripheral nervous system. AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Beside toxins, drugs for treatment of Alzheimer's disease and myasthenia gravis, such as galantamine, donepezil, rivastigmine, tacrine, huperzine, pyridostigmine and neostigmine, are known. Areas covered: The review gives an overview of the importance of the cholinergic nervous system, the biochemistry of AChE and the role of AChE inhibitors. Current efforts to introduce potent drugs for Alzheimer's disease therapy and reduce toxicity, while keeping the maximal pharmacological effect, are also discussed. Expert opinion: The current research effort into AChE inhibitors can be divided into two categories. First, new toxins useful for agricultur

Název v anglickém jazyce

Acetylcholinesterase inhibitors: a patent review (2008 - present)

Popis výsledku anglicky

Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are present in the body in large amounts. AChE is an important part of the cholinergic nervous system taking place in the central and peripheral nervous system. AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Beside toxins, drugs for treatment of Alzheimer's disease and myasthenia gravis, such as galantamine, donepezil, rivastigmine, tacrine, huperzine, pyridostigmine and neostigmine, are known. Areas covered: The review gives an overview of the importance of the cholinergic nervous system, the biochemistry of AChE and the role of AChE inhibitors. Current efforts to introduce potent drugs for Alzheimer's disease therapy and reduce toxicity, while keeping the maximal pharmacological effect, are also discussed. Expert opinion: The current research effort into AChE inhibitors can be divided into two categories. First, new toxins useful for agricultur

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LH11023" target="_blank" >LH11023: Vylepšení vakcinační účinnosti pomocí cholinergní protizánětlivé dráhy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Expert Opinion on Therapeutic Patents

ISSN

1354-3776

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

871-886

Kód UT WoS článku

000306603000002

EID výsledku v databázi Scopus

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