Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874690" target="_blank" >RIV/60162694:G44__/12:43874690 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10124868

Výsledek na webu

<a href="http://www.zsf.jcu.cz/jab/10_1/vavrova10_1.htm" target="_blank" >http://www.zsf.jcu.cz/jab/10_1/vavrova10_1.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-012-0002-2" target="_blank" >10.2478/v10136-012-0002-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents

Popis výsledku v původním jazyce

Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long termradiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C-60(OH)(24), dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants.

Název v anglickém jazyce

Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents

Popis výsledku anglicky

Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long termradiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C-60(OH)(24), dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/OVUOFVZ200806" target="_blank" >OVUOFVZ200806: RONSDOZ - Neinvazivní stanovení prozánětlivých ukazatelů oxidačního stresu u ozářených jako indikátor obdržené dávky záření. Ochranný efekt acetyl-L-karnitinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine - print

ISSN

1214-021X

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000300403600001

EID výsledku v databázi Scopus

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