Tacrine can suppress immunity response to tularemia in BALB/c mouse model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874947" target="_blank" >RIV/60162694:G44__/13:43874947 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X14600892?via=ihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X14600892?via=ihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-012-0021-z" target="_blank" >10.2478/v10136-012-0021-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tacrine can suppress immunity response to tularemia in BALB/c mouse model

Popis výsledku v původním jazyce

Tacrine is an inhibitor of enzyme acetylcholinesterase (AChE). In the past, it was used for the treatment of cognitive dysfunction during vascular dementia and Alzheimer disease. Some works have concluded that AChE inhibitors can modulate immune response, and for this reason, we decided to investigate the immune response to a model bacterial disease - tularemia - for which both innate and specific immunity are necessary to resolve the disease. We used 64 BALB/c mice divided into eight groups exposed variously to saline, tacrine in a dose of 20.0-500 mu g/kg, infection with tularemia and infection with the contemporary application of tacrine. The mice were euthanized three days after the start of the experiment. We proved a significant reduction in thelevels of interleukin-6 (IL-6) and interferon gamma (IFN-gamma) in a dose response manner in the infected animals in the course of tularemia. Moreover, tacrine caused a significant increase of the bacterial burden in the liver and spleen.

Název v anglickém jazyce

Tacrine can suppress immunity response to tularemia in BALB/c mouse model

Popis výsledku anglicky

Tacrine is an inhibitor of enzyme acetylcholinesterase (AChE). In the past, it was used for the treatment of cognitive dysfunction during vascular dementia and Alzheimer disease. Some works have concluded that AChE inhibitors can modulate immune response, and for this reason, we decided to investigate the immune response to a model bacterial disease - tularemia - for which both innate and specific immunity are necessary to resolve the disease. We used 64 BALB/c mice divided into eight groups exposed variously to saline, tacrine in a dose of 20.0-500 mu g/kg, infection with tularemia and infection with the contemporary application of tacrine. The mice were euthanized three days after the start of the experiment. We proved a significant reduction in thelevels of interleukin-6 (IL-6) and interferon gamma (IFN-gamma) in a dose response manner in the infected animals in the course of tularemia. Moreover, tacrine caused a significant increase of the bacterial burden in the liver and spleen.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH11023" target="_blank" >LH11023: Vylepšení vakcinační účinnosti pomocí cholinergní protizánětlivé dráhy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine - print

ISSN

1214-021X

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

187-193

Kód UT WoS článku

000315854000007

EID výsledku v databázi Scopus

—