Melatonin Changes tularemia progression in a BALB/c mouse model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874970" target="_blank" >RIV/60162694:G44__/13:43874970 - isvavai.cz</a>

Výsledek na webu

<a href="http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327" target="_blank" >http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5897/AJPP2013.3496" target="_blank" >10.5897/AJPP2013.3496</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Melatonin Changes tularemia progression in a BALB/c mouse model

Popis výsledku v původním jazyce

Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 ?g/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent t

Název v anglickém jazyce

Melatonin Changes tularemia progression in a BALB/c mouse model

Popis výsledku anglicky

Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 ?g/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

African Journal of Pharmacy and Pharmacology

ISSN

1996-0816

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

27

Stát vydavatele periodika

NG - Nigérijská federativní republika

Počet stran výsledku

7

Strana od-do

1917-1923

Kód UT WoS článku

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EID výsledku v databázi Scopus

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