Impact of caffeine on tularemia progression in a mouse model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875483" target="_blank" >RIV/60162694:G44__/15:43875483 - isvavai.cz</a>

Výsledek na webu

<a href="http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2" target="_blank" >http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of caffeine on tularemia progression in a mouse model

Popis výsledku v původním jazyce

Caffeine is an alkaloid acting as an antagonist on adenosine receptors; however, the other targets for caffeine are known as well.Not much is known about effect of caffeine on immunity. In this work, we have hypothesized that caffeine can cause alteration of infectious disease progression. Tularemia, a zoonotic disease caused by Francisellatularensis, was used as the model disease and BALB/c mice were used as an in vivo model. Interleukines (IL) 1b, 2, 4, 6 and interferon g (IFN-g) were assayed by enzyme linked immuno-sorbent assay (ELISA) from plasma and bacterial burden was tested in spleen. We proved that caffeine caused increase of bacterial burden in the spleen in dose response manner. Oppose to this, IL-6 and IFN-gwere decreased in dose response manner. Caffeine seems to be able to modulate tularemia progression. Impact on neutrophils via adenosine receptors and on macrophages via cholinergic anti-inflammatory pathway is the most probable explanation.

Název v anglickém jazyce

Impact of caffeine on tularemia progression in a mouse model

Popis výsledku anglicky

Caffeine is an alkaloid acting as an antagonist on adenosine receptors; however, the other targets for caffeine are known as well.Not much is known about effect of caffeine on immunity. In this work, we have hypothesized that caffeine can cause alteration of infectious disease progression. Tularemia, a zoonotic disease caused by Francisellatularensis, was used as the model disease and BALB/c mice were used as an in vivo model. Interleukines (IL) 1b, 2, 4, 6 and interferon g (IFN-g) were assayed by enzyme linked immuno-sorbent assay (ELISA) from plasma and bacterial burden was tested in spleen. We proved that caffeine caused increase of bacterial burden in the spleen in dose response manner. Oppose to this, IL-6 and IFN-gwere decreased in dose response manner. Caffeine seems to be able to modulate tularemia progression. Impact on neutrophils via adenosine receptors and on macrophages via cholinergic anti-inflammatory pathway is the most probable explanation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pure and Applied Microbiology

ISSN

0973-7510

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

6

Strana od-do

913-918

Kód UT WoS článku

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EID výsledku v databázi Scopus

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