Caffeine downregulates antibody production in a mouse model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875350" target="_blank" >RIV/60162694:G44__/15:43875350 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X14000799" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X14000799</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2014.09.001" target="_blank" >10.1016/j.jab.2014.09.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Caffeine downregulates antibody production in a mouse model

Popis výsledku v původním jazyce

Caffeine is a secondary plant metabolite found in coffee and tea. Its major pathway is interaction with adenosine receptors. Minor pathways are also known. An effect of caffeine on immunity has been proposed. In this paper, the role of caffeine on the immune system was studied, using a BALB/c mouse model. The animals received saline (controls), keyhole limpet hemocyanin (KLH) 1 mg/kg or caffeine (alone or in combination with KLH) in doses of 1-16 mg/kg. The mice were sacrificed 1-7 days later and plasmalevels of interleukin (IL) 2, 4, 6, 10, 12 and antibodies against KLH were determined by enzyme linked immunosorbent assay (ELISA). Caffeine caused a significant decrease in KLH-stimulated antibody production. The effect was dose dependent. There were similar findings for IL-2 and IL-4 but not for IL-6, IL-10 and IL-12. The significance of the findings is discussed with extrapolation to humans based on caffeine doses used in the study and the amount of caffeine in available beverages.

Název v anglickém jazyce

Caffeine downregulates antibody production in a mouse model

Popis výsledku anglicky

Caffeine is a secondary plant metabolite found in coffee and tea. Its major pathway is interaction with adenosine receptors. Minor pathways are also known. An effect of caffeine on immunity has been proposed. In this paper, the role of caffeine on the immune system was studied, using a BALB/c mouse model. The animals received saline (controls), keyhole limpet hemocyanin (KLH) 1 mg/kg or caffeine (alone or in combination with KLH) in doses of 1-16 mg/kg. The mice were sacrificed 1-7 days later and plasmalevels of interleukin (IL) 2, 4, 6, 10, 12 and antibodies against KLH were determined by enzyme linked immunosorbent assay (ELISA). Caffeine caused a significant decrease in KLH-stimulated antibody production. The effect was dose dependent. There were similar findings for IL-2 and IL-4 but not for IL-6, IL-10 and IL-12. The significance of the findings is discussed with extrapolation to humans based on caffeine doses used in the study and the amount of caffeine in available beverages.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LH11023" target="_blank" >LH11023: Vylepšení vakcinační účinnosti pomocí cholinergní protizánětlivé dráhy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

000350670600001

EID výsledku v databázi Scopus

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