B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875161" target="_blank" >RIV/60162694:G44__/14:43875161 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0882401014001235" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0882401014001235</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.micpath.2014.08.009" target="_blank" >10.1016/j.micpath.2014.08.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection

Popis výsledku v původním jazyce

Francisella tularensis, a facultative intracellular Gram-negative bacterium, causes the illness tularemia. The infection of mice with live vaccine strain is considered to be a model of human tularemia. E tularensis infects predominantly such phagocytic cells as macrophages or neutrophils, but it also infects non-phagocytic hepatocytes, epithelial cells, and murine and human B cell lines. Based on work with the murine tularemia model, we report here that F. tularensis LVS infects peritoneal CD19(+) cells- exclusively B-la cells early after intraperitoneal infection in vivo. The peritoneal and consequently spleen CD19+ cells are activated by the F. tularensis LVS infection to express the activation markers from MHC class II, CD25, CD54, CD69, and the co-stimulatory molecules CD80 and CD86. As early as 12 h post-infection, the peritoneal CD19(+) cells produce IFN-gamma, IL-1 beta, IL-4, IL-6, IL-12, IL-17, IL-23, and THE-alpha. The spleen CD19(+) cells respond to infection with some dela

Název v anglickém jazyce

B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection

Popis výsledku anglicky

Francisella tularensis, a facultative intracellular Gram-negative bacterium, causes the illness tularemia. The infection of mice with live vaccine strain is considered to be a model of human tularemia. E tularensis infects predominantly such phagocytic cells as macrophages or neutrophils, but it also infects non-phagocytic hepatocytes, epithelial cells, and murine and human B cell lines. Based on work with the murine tularemia model, we report here that F. tularensis LVS infects peritoneal CD19(+) cells- exclusively B-la cells early after intraperitoneal infection in vivo. The peritoneal and consequently spleen CD19+ cells are activated by the F. tularensis LVS infection to express the activation markers from MHC class II, CD25, CD54, CD69, and the co-stimulatory molecules CD80 and CD86. As early as 12 h post-infection, the peritoneal CD19(+) cells produce IFN-gamma, IL-1 beta, IL-4, IL-6, IL-12, IL-17, IL-23, and THE-alpha. The spleen CD19(+) cells respond to infection with some dela

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP302%2F11%2F1631" target="_blank" >GAP302/11/1631: Úloha B buněk v přirozené a adaptivní imunitní odpovědi proti infekci Francisella tularensis u myší.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microbial Pathogenesis

ISSN

0882-4010

e-ISSN

—

Svazek periodika

75

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

49-58

Kód UT WoS článku

000342654900008

EID výsledku v databázi Scopus

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