Caffeine alters oxidative homeostasis in the body of BALB/c mice
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875215" target="_blank" >RIV/60162694:G44__/14:43875215 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.elis.sk/download_file.php?product_id=4056&session_id=gc6otkblo722349n4fkp8heih0" target="_blank" >http://www.elis.sk/download_file.php?product_id=4056&session_id=gc6otkblo722349n4fkp8heih0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2014_135" target="_blank" >10.4149/BLL_2014_135</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Caffeine alters oxidative homeostasis in the body of BALB/c mice
Popis výsledku v původním jazyce
Caffeine is a metabolite from coffea genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The completemechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1 - 64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicates up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, casp
Název v anglickém jazyce
Caffeine alters oxidative homeostasis in the body of BALB/c mice
Popis výsledku anglicky
Caffeine is a metabolite from coffea genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The completemechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1 - 64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicates up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, casp
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bratislava Medical Journal-Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
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Svazek periodika
115
Číslo periodika v rámci svazku
11
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
5
Strana od-do
699-703
Kód UT WoS článku
000346550800006
EID výsledku v databázi Scopus
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