Cytokines and radiation-induced pulmonary injuries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889783" target="_blank" >RIV/60162694:G44__/18:43889783 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251431/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251431/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jrr/rry067" target="_blank" >10.1093/jrr/rry067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cytokines and radiation-induced pulmonary injuries

Popis výsledku v původním jazyce

Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damages can occur in alveolar epithelium and capillary endothelium. These damages may result in the radiation-induced pneumonitis and/or fibrosis. While describing lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions in the individual stages. We discuss the relationship between radiation and cytokines and their direct or indirect effects in the formation and development of radiation injuries. Despite that this topic has been intensively studied and debated for years, there is still not complete understanding of cytokine roles. Because experimental data on cytokines&apos; involvement are fragmented across a large number of experimental studies, this review brings together current knowledge. Cytokines are investigated not only as molecular factors linking with signaling network in pathological processes but also for their diagnostic potential. Much concentrated effort has been made to find the correct protein of the immune system having positive correlation between serum levels and tissue damages. Elucidating a correlation between extent of radiation-induced pulmonary injuries and one or more key cytokines that initiate and control that damage may reveal and improve the efficiency of radiotherapy in cancer treatment and the well-being of patients

Název v anglickém jazyce

Cytokines and radiation-induced pulmonary injuries

Popis výsledku anglicky

Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damages can occur in alveolar epithelium and capillary endothelium. These damages may result in the radiation-induced pneumonitis and/or fibrosis. While describing lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions in the individual stages. We discuss the relationship between radiation and cytokines and their direct or indirect effects in the formation and development of radiation injuries. Despite that this topic has been intensively studied and debated for years, there is still not complete understanding of cytokine roles. Because experimental data on cytokines&apos; involvement are fragmented across a large number of experimental studies, this review brings together current knowledge. Cytokines are investigated not only as molecular factors linking with signaling network in pathological processes but also for their diagnostic potential. Much concentrated effort has been made to find the correct protein of the immune system having positive correlation between serum levels and tissue damages. Elucidating a correlation between extent of radiation-induced pulmonary injuries and one or more key cytokines that initiate and control that damage may reveal and improve the efficiency of radiotherapy in cancer treatment and the well-being of patients

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Radiation Research

ISSN

0449-3060

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

45

Strana od-do

709-753

Kód UT WoS článku

000452745600005

EID výsledku v databázi Scopus

2-s2.0-85057154959