Kinetics of Myristic Acid Following Accidentally Induced Septic Response

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00555145" target="_blank" >RIV/60162694:G44__/19:00555145 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10401478 RIV/00023884:_____/19:00008606 RIV/00064190:_____/19:N0000115

Výsledek na webu

<a href="https://pmr.lf1.cuni.cz/120/2/0103/" target="_blank" >https://pmr.lf1.cuni.cz/120/2/0103/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/23362936.2019.15" target="_blank" >10.14712/23362936.2019.15</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kinetics of Myristic Acid Following Accidentally Induced Septic Response

Popis výsledku v původním jazyce

Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.

Název v anglickém jazyce

Kinetics of Myristic Acid Following Accidentally Induced Septic Response

Popis výsledku anglicky

Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

2336-2936

Svazek periodika

120

Číslo periodika v rámci svazku

2-3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

103-106

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85072977213