Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00555876" target="_blank" >RIV/60162694:G44__/20:00555876 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.eurekaselect.com/169484/article" target="_blank" >http://www.eurekaselect.com/169484/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867326666190130161202" target="_blank" >10.2174/0929867326666190130161202</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase
Popis výsledku v původním jazyce
Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer's disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.
Název v anglickém jazyce
Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase
Popis výsledku anglicky
Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer's disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/TH03030336" target="_blank" >TH03030336: Kolorimetrický senzor pro diagnostiku otrav pesticidy</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
1875-533X
Svazek periodika
27
Číslo periodika v rámci svazku
18
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
18
Strana od-do
2994-3011
Kód UT WoS článku
000539113400005
EID výsledku v databázi Scopus
2-s2.0-85086243749