Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F23%3A00558405" target="_blank" >RIV/60162694:G44__/23:00558405 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.eurekaselect.com/article/122525" target="_blank" >https://www.eurekaselect.com/article/122525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1389557522666220413103529" target="_blank" >10.2174/1389557522666220413103529</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review

Popis výsledku v původním jazyce

Caffeine, a simple purine alkaloid with the proper chemical name 1,3,7-trimethylpurine-2,6-dione, is an abundant compound present in coffee, food and drugs. It interacts with various pathways of which antagonism of adenosine receptors is the most significant but the other physiological pathways can be influenced by caffeine as well. Interaction with glutamate and dopamine neurotransmission pathways, competition with other substrates on cytochrome P450, non-competitive inhibition of acetylcholinesterase, blocking of nicotinic acetylcholine receptor and competitive inhibition of cyclic nucleotide phosphodiesterase can be mentioned. Because of caffeine availability in foods, beverages and drugs, it has practical relevance even if the effect is weak. Intake of coffee containing edibles for a long period or even for a substantial part of life makes caffeine ' s impact significant. Low acute and chronic toxicity of caffeine is another important specification. The discoveries from the last few years point to the fact that caffeine would interfere with the progression of some age-related neurodegenerative disorders like Alzheimer's and Parkinson's diseases and dementia with Lewy bodies. In this review article, the recent findings about caffeine ' s impact on neurodegenerative diseases are presented and important facts about the caffeine effect, including the substantial discoveries, are described.

Název v anglickém jazyce

Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review

Popis výsledku anglicky

Caffeine, a simple purine alkaloid with the proper chemical name 1,3,7-trimethylpurine-2,6-dione, is an abundant compound present in coffee, food and drugs. It interacts with various pathways of which antagonism of adenosine receptors is the most significant but the other physiological pathways can be influenced by caffeine as well. Interaction with glutamate and dopamine neurotransmission pathways, competition with other substrates on cytochrome P450, non-competitive inhibition of acetylcholinesterase, blocking of nicotinic acetylcholine receptor and competitive inhibition of cyclic nucleotide phosphodiesterase can be mentioned. Because of caffeine availability in foods, beverages and drugs, it has practical relevance even if the effect is weak. Intake of coffee containing edibles for a long period or even for a substantial part of life makes caffeine ' s impact significant. Low acute and chronic toxicity of caffeine is another important specification. The discoveries from the last few years point to the fact that caffeine would interfere with the progression of some age-related neurodegenerative disorders like Alzheimer's and Parkinson's diseases and dementia with Lewy bodies. In this review article, the recent findings about caffeine ' s impact on neurodegenerative diseases are presented and important facts about the caffeine effect, including the substantial discoveries, are described.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mini-Reviews in Medicinal Chemistry

ISSN

1389-5575

e-ISSN

1875-5607

Svazek periodika

22

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

10

Strana od-do

2726-2735

Kód UT WoS článku

000864627500004

EID výsledku v databázi Scopus

2-s2.0-85138884775