Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG45__%2F24%3A00559074" target="_blank" >RIV/60162694:G45__/24:00559074 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.shd-pub.org.rs/index.php/JSCS/article/view/12165" target="_blank" >https://www.shd-pub.org.rs/index.php/JSCS/article/view/12165</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2298/JSC221207025R" target="_blank" >10.2298/JSC221207025R</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Popis výsledku v původním jazyce

The report describes the development of methods for rapid and simple identification of Adamsite in mobile laboratory conditions using a field gas chromatograph coupled with mass spectrometer. Adamsite is a chemical warfare agent with unique properties that cannot be analyzed without conversion to a volatile derivative. Derivatization procedures with 5 aliphatic thiols (ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol and 1-hexanethiol) were developed and compared. The retention characteristics of the derivatization products, peak characteristics and the formation of unwanted artifacts in the chromatograms were monitored. The influence of the reaction media and the time dependence of the reaction were also objects of interest. Other investigated parameters were the optimal reaction temperature and the volume of the derivatization agent. Mass spectra of newly created substances that are not yet included in the chemical weapons related databases were recorded. With optimal reagents (1-butanethiol and 1-hexanethiol), calibration procedures for analyte determination were subsequently developed, and the methods were verified during the Adamsite identification test in selected environmental and urban matrices.

Název v anglickém jazyce

Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Popis výsledku anglicky

The report describes the development of methods for rapid and simple identification of Adamsite in mobile laboratory conditions using a field gas chromatograph coupled with mass spectrometer. Adamsite is a chemical warfare agent with unique properties that cannot be analyzed without conversion to a volatile derivative. Derivatization procedures with 5 aliphatic thiols (ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol and 1-hexanethiol) were developed and compared. The retention characteristics of the derivatization products, peak characteristics and the formation of unwanted artifacts in the chromatograms were monitored. The influence of the reaction media and the time dependence of the reaction were also objects of interest. Other investigated parameters were the optimal reaction temperature and the volume of the derivatization agent. Mass spectra of newly created substances that are not yet included in the chemical weapons related databases were recorded. With optimal reagents (1-butanethiol and 1-hexanethiol), calibration procedures for analyte determination were subsequently developed, and the methods were verified during the Adamsite identification test in selected environmental and urban matrices.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Serbian Chemical Society

ISSN

0352-5139

e-ISSN

—

Svazek periodika

88

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

14

Strana od-do

639-652

Kód UT WoS článku

001015385100001

EID výsledku v databázi Scopus

2-s2.0-85164802012