Potentiation of the in vitro Antistaphylococcal Effect of Oxacillin and Tetracycline by the Anti-Inflammatory Drug Diacetyl Rhein
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A69853" target="_blank" >RIV/60460709:41210/14:69853 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60460709:41340/14:69853
Výsledek na webu
<a href="http://dx.doi.org/10.1159/000363730" target="_blank" >http://dx.doi.org/10.1159/000363730</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000363730" target="_blank" >10.1159/000363730</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Potentiation of the in vitro Antistaphylococcal Effect of Oxacillin and Tetracycline by the Anti-Inflammatory Drug Diacetyl Rhein
Popis výsledku v původním jazyce
Background: The anti-inflammatory drug diacetyl rhein has been found to possess promising antistaphylococcal effects against various drug-resistant strains in our previous study. In the present work, we explored the in vitro combinatory interactions of diacetyl rhein with oxacillin and tetracycline against 13 standard strains and clinical isolates of Staphylococcus aureus, including those resistant to erythromycin, methicillin and tetracycline. Methods: Minimum inhibitory concentrations were determinedby broth microdilution assay, and the effects of combinations were evaluated according to the sum of fractional inhibitory concentrations (?FICs). Results: Synergistic or additive effects were observed against all S. aureus strains (?FIC 0.258?1), whereas diacetyl rhein - oxacillin appeared to be the most effective combination, synergistically inhibiting the growth of 4 strains tested. Conclusion: To our best knowledge, this is the first report on a synergistic antibacterial effect of di
Název v anglickém jazyce
Potentiation of the in vitro Antistaphylococcal Effect of Oxacillin and Tetracycline by the Anti-Inflammatory Drug Diacetyl Rhein
Popis výsledku anglicky
Background: The anti-inflammatory drug diacetyl rhein has been found to possess promising antistaphylococcal effects against various drug-resistant strains in our previous study. In the present work, we explored the in vitro combinatory interactions of diacetyl rhein with oxacillin and tetracycline against 13 standard strains and clinical isolates of Staphylococcus aureus, including those resistant to erythromycin, methicillin and tetracycline. Methods: Minimum inhibitory concentrations were determinedby broth microdilution assay, and the effects of combinations were evaluated according to the sum of fractional inhibitory concentrations (?FICs). Results: Synergistic or additive effects were observed against all S. aureus strains (?FIC 0.258?1), whereas diacetyl rhein - oxacillin appeared to be the most effective combination, synergistically inhibiting the growth of 4 strains tested. Conclusion: To our best knowledge, this is the first report on a synergistic antibacterial effect of di
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
GM - Potravinářství
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
CHEMOTHERAPY
ISSN
0009-3157
e-ISSN
—
Svazek periodika
59
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
6
Strana od-do
447-452
Kód UT WoS článku
000341818900009
EID výsledku v databázi Scopus
—