In vitro Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against Staphylococcus aureus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F15%3A66019" target="_blank" >RIV/60460709:41210/15:66019 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41340/15:66019

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ptr.5237" target="_blank" >http://dx.doi.org/10.1002/ptr.5237</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ptr.5237" target="_blank" >10.1002/ptr.5237</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against Staphylococcus aureus

Popis výsledku v původním jazyce

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a bicyclic naphthoquinone naturally distributed among Plumbago species, has been reported to have antimicrobial activity against a wide range of microorganisms. In this study, plumbagin was examined forits combinatory antimicrobial effect with tetracycline or oxacillin against nine strains of Staphylococcus aureus, including its methicillin- and multidrug-resistant strains.Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated according to the sum of fractional inhibitory concentration (?FIC) indices. Additive interactions were obtained for both combinations against most of the strains tested. Synergy was obtained for combination with oxacillin against two out of seven strains (?FIC range 0.273?0.281), both were methicillin resistant. Our results proved plumbagin as a compound suitable for anti-Staphylococcal combinatory testing. Moreover, to the best of o

Název v anglickém jazyce

In vitro Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against Staphylococcus aureus

Popis výsledku anglicky

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a bicyclic naphthoquinone naturally distributed among Plumbago species, has been reported to have antimicrobial activity against a wide range of microorganisms. In this study, plumbagin was examined forits combinatory antimicrobial effect with tetracycline or oxacillin against nine strains of Staphylococcus aureus, including its methicillin- and multidrug-resistant strains.Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated according to the sum of fractional inhibitory concentration (?FIC) indices. Additive interactions were obtained for both combinations against most of the strains tested. Synergy was obtained for combination with oxacillin against two out of seven strains (?FIC range 0.273?0.281), both were methicillin resistant. Our results proved plumbagin as a compound suitable for anti-Staphylococcal combinatory testing. Moreover, to the best of o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GM - Potravinářství

OECD FORD obor

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Projekt

—

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PHYTOTHERAPY RESEARCH

ISSN

0951-418X

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

144-147

Kód UT WoS článku

000348060300022

EID výsledku v databázi Scopus

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