Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A79183" target="_blank" >RIV/60460709:41210/20:79183 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/30686246/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/30686246/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867326666190125155947" target="_blank" >10.2174/0929867326666190125155947</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status

Popis výsledku v původním jazyce

BACKGROUND: Migraine may be described as a headache with moderate to extreme pain that is often accompanied by incapacitating neurological symptoms. It is estimated that 12% of the world population suffers from migraine. Although a number of drugs have been used for treatment of migraine, most of these are not effective for every patient and may have undesirable side-effects. Thus there is an enormous unmet need in current migraine therapy for discovering safer and more effective agents. METHODS: The information summarized in this review was obtained through extensive literature review and search of relevant books and articles with the use of Web of Knowledge and SciVerse Scopus databases. RESULTS: Greater understanding of the molecular mechanisms underlying the etiopathogenesis of migraine is helpful in identifying novel targets for antimigraine drugs such as cannabinoid, histamine, and melatonin receptors. In the past, natural product-derived constituents have served as an invaluable source of

Název v anglickém jazyce

Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status

Popis výsledku anglicky

BACKGROUND: Migraine may be described as a headache with moderate to extreme pain that is often accompanied by incapacitating neurological symptoms. It is estimated that 12% of the world population suffers from migraine. Although a number of drugs have been used for treatment of migraine, most of these are not effective for every patient and may have undesirable side-effects. Thus there is an enormous unmet need in current migraine therapy for discovering safer and more effective agents. METHODS: The information summarized in this review was obtained through extensive literature review and search of relevant books and articles with the use of Web of Knowledge and SciVerse Scopus databases. RESULTS: Greater understanding of the molecular mechanisms underlying the etiopathogenesis of migraine is helpful in identifying novel targets for antimigraine drugs such as cannabinoid, histamine, and melatonin receptors. In the past, natural product-derived constituents have served as an invaluable source of

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

1875-533X

Svazek periodika

27

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

25

Strana od-do

3784-3808

Kód UT WoS článku

000546321000002

EID výsledku v databázi Scopus

2-s2.0-85073991246