New perspective on the geographic distribution and evolution of Lymphocytic Choriominingitis, Central Europe
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A88293" target="_blank" >RIV/60460709:41210/21:88293 - isvavai.cz</a>
Výsledek na webu
<a href="https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article" target="_blank" >https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3201/eid2710.210224" target="_blank" >10.3201/eid2710.210224</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New perspective on the geographic distribution and evolution of Lymphocytic Choriominingitis, Central Europe
Popis výsledku v původním jazyce
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis, in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic-Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.
Název v anglickém jazyce
New perspective on the geographic distribution and evolution of Lymphocytic Choriominingitis, Central Europe
Popis výsledku anglicky
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis, in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic-Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30303 - Infectious Diseases
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
EMERGING INFECTIOUS DISEASES
ISSN
1080-6040
e-ISSN
1080-6059
Svazek periodika
27
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
10
Strana od-do
2638-2647
Kód UT WoS článku
000710239500015
EID výsledku v databázi Scopus
2-s2.0-85115432750