Multiple functions of CREB-binding protein during postembryonic development: identification of target genes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41320%2F17%3A76003" target="_blank" >RIV/60460709:41320/17:76003 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1186/s12864-017-4373-3" target="_blank" >http://dx.doi.org/10.1186/s12864-017-4373-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12864-017-4373-3" target="_blank" >10.1186/s12864-017-4373-3</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Multiple functions of CREB-binding protein during postembryonic development: identification of target genes
Popis výsledku v původním jazyce
Background: Juvenile hormones (JH) and ecdysteroids control postembryonic development in insects. They serve as valuable targets for pest management. Hence, understanding the molecular mechanisms of their action is of crucial importance. CREB-binding protein (CBP) is a universal transcriptional co-regulator. It controls the expression of several genes including those from hormone signaling pathways through co-activation of many transcription factors. However, the role of CBP during postembryonic development in insects is not well understood. Therefore, we have studied the role of CBP in postembryonic development in Tribolium, a model coleopteran insect. Results: CBP is ubiquitously expressed in the red flour beetle, Tribolium castaneum. RNA interference (RNAi) mediated knockdown of CBP resulted in a decrease in JH induction of Kr-h1 gene expression in Tribolium larvae and led to a block in their development. Moreover, the injection of CBP double-stranded RNA (dsRNA) showed lethal phenotypes within
Název v anglickém jazyce
Multiple functions of CREB-binding protein during postembryonic development: identification of target genes
Popis výsledku anglicky
Background: Juvenile hormones (JH) and ecdysteroids control postembryonic development in insects. They serve as valuable targets for pest management. Hence, understanding the molecular mechanisms of their action is of crucial importance. CREB-binding protein (CBP) is a universal transcriptional co-regulator. It controls the expression of several genes including those from hormone signaling pathways through co-activation of many transcription factors. However, the role of CBP during postembryonic development in insects is not well understood. Therefore, we have studied the role of CBP in postembryonic development in Tribolium, a model coleopteran insect. Results: CBP is ubiquitously expressed in the red flour beetle, Tribolium castaneum. RNA interference (RNAi) mediated knockdown of CBP resulted in a decrease in JH induction of Kr-h1 gene expression in Tribolium larvae and led to a block in their development. Moreover, the injection of CBP double-stranded RNA (dsRNA) showed lethal phenotypes within
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10606 - Microbiology
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BMC GENOMICS
ISSN
1471-2164
e-ISSN
—
Svazek periodika
18
Číslo periodika v rámci svazku
996
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
14
Strana od-do
1-14
Kód UT WoS článku
000419229900002
EID výsledku v databázi Scopus
2-s2.0-85039733795