Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41320%2F18%3A78800" target="_blank" >RIV/60460709:41320/18:78800 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1186/s12864-018-5323-4" target="_blank" >http://dx.doi.org/10.1186/s12864-018-5323-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12864-018-5323-4" target="_blank" >10.1186/s12864-018-5323-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action
Popis výsledku v původním jazyce
BackgroundEpigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.ResultsExposure of Tribolium castaneum cells (TcA cells) to JH or TSA caused an increase in expression of Kr-h1 (a known JH-response gene) and 31 or 698 other genes respectively. Knockdown of the gene coding for CBP caused a decrease in the expression of 456 genes including Kr-h1. Int
Název v anglickém jazyce
Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action
Popis výsledku anglicky
BackgroundEpigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.ResultsExposure of Tribolium castaneum cells (TcA cells) to JH or TSA caused an increase in expression of Kr-h1 (a known JH-response gene) and 31 or 698 other genes respectively. Knockdown of the gene coding for CBP caused a decrease in the expression of 456 genes including Kr-h1. Int
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
20801 - Environmental biotechnology
Návaznosti výsledku
Projekt
—
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BMC GENOMICS
ISSN
1471-2164
e-ISSN
—
Svazek periodika
19
Číslo periodika v rámci svazku
DEC2018
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
15
Strana od-do
1-15
Kód UT WoS článku
000453235700004
EID výsledku v databázi Scopus
2-s2.0-85058599981