Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41330%2F20%3A85107" target="_blank" >RIV/60460709:41330/20:85107 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2227-9059/8/5/132" target="_blank" >https://www.mdpi.com/2227-9059/8/5/132</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines8050132" target="_blank" >10.3390/biomedicines8050132</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments

Popis výsledku v původním jazyce

While few studies have revealed the biological properties of brassicasterol, a phytosterol, against some biological and molecular targets, it is believed that there are still many activities yet to be studied. In this work, brassicasterol exerts a therapeutic utility in an in vitro setting against herpes simplex virus type 1 (HSV 1) and Mycobacterium tuberculosis (Mtb) as well as a considerable inhibitory property against human angiotensin converting enzyme (ACE) that plays a dynamic role in regulating blood pressure. The antireplicative effect of brassicasterol against HSV 1 is remarkably detected (50 percent inhibitory concentration (IC50) 1,2 mu M, selectivity index (SI) 41,7), while the potency of its effect is ameliorated through the combination with standard acyclovir with proper SI (IC50 0,7 mu M, SI 71,4). Moreover, the capacity of this compound to induce an adequate level of antituberculosis activity against all Mtb strains examined (minimum inhibitory concentration values ranging from 1,9 t

Název v anglickém jazyce

Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments

Popis výsledku anglicky

While few studies have revealed the biological properties of brassicasterol, a phytosterol, against some biological and molecular targets, it is believed that there are still many activities yet to be studied. In this work, brassicasterol exerts a therapeutic utility in an in vitro setting against herpes simplex virus type 1 (HSV 1) and Mycobacterium tuberculosis (Mtb) as well as a considerable inhibitory property against human angiotensin converting enzyme (ACE) that plays a dynamic role in regulating blood pressure. The antireplicative effect of brassicasterol against HSV 1 is remarkably detected (50 percent inhibitory concentration (IC50) 1,2 mu M, selectivity index (SI) 41,7), while the potency of its effect is ameliorated through the combination with standard acyclovir with proper SI (IC50 0,7 mu M, SI 71,4). Moreover, the capacity of this compound to induce an adequate level of antituberculosis activity against all Mtb strains examined (minimum inhibitory concentration values ranging from 1,9 t

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicines

ISSN

2227-9059

e-ISSN

2227-9059

Svazek periodika

8

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

000540842200038

EID výsledku v databázi Scopus

2-s2.0-85087088356