Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43892807" target="_blank" >RIV/60461373:22310/11:43892807 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/11:00368922 RIV/60461373:22810/11:43892807

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.molstruc.2011.08.002" target="_blank" >http://dx.doi.org/10.1016/j.molstruc.2011.08.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molstruc.2011.08.002" target="_blank" >10.1016/j.molstruc.2011.08.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles

Popis výsledku v původním jazyce

Five flavin (isoalloxazine) and alloxazine adducts with O-nucleophiles, 5-ethyl-4a-hydroxy-3,7,8,10-tetramethyl-4a,5-dihydroisoalloxazine (1a-OH), 5-ethyl-4a-hydroxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OH), 5-ethyl-4a-methoxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OMe), 5-ethyl-4a-hydroxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OH) and 5-ethyl-4a-methoxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OMe) were prepared from the corresponding salts, 5-ethyl-3,7,8,10-tetramethylisoalloxazinium (la),5-ethyl-3,10-dimethylisoalloxazinium (1b) and 5-ethyl-1,3-dimethylalloxazinium (2a) perchlorates by the addition of a nucleophile (water or methanol) and triethylamine as a base. The prepared adducts represent artificial analogs of Flavin cofactor derivatives which are essential for the functioning of flavoenzymes. They were characterized by (1)H and (13)C NMR, HR-MS and UV-VIS spectra. In the cases of la-OH, 1b-OH, and 2a-OMe, the crystal structures were determined by X-ray diffraction

Název v anglickém jazyce

Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles

Popis výsledku anglicky

Five flavin (isoalloxazine) and alloxazine adducts with O-nucleophiles, 5-ethyl-4a-hydroxy-3,7,8,10-tetramethyl-4a,5-dihydroisoalloxazine (1a-OH), 5-ethyl-4a-hydroxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OH), 5-ethyl-4a-methoxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OMe), 5-ethyl-4a-hydroxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OH) and 5-ethyl-4a-methoxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OMe) were prepared from the corresponding salts, 5-ethyl-3,7,8,10-tetramethylisoalloxazinium (la),5-ethyl-3,10-dimethylisoalloxazinium (1b) and 5-ethyl-1,3-dimethylalloxazinium (2a) perchlorates by the addition of a nucleophile (water or methanol) and triethylamine as a base. The prepared adducts represent artificial analogs of Flavin cofactor derivatives which are essential for the functioning of flavoenzymes. They were characterized by (1)H and (13)C NMR, HR-MS and UV-VIS spectra. In the cases of la-OH, 1b-OH, and 2a-OMe, the crystal structures were determined by X-ray diffraction

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA203%2F07%2F1246" target="_blank" >GA203/07/1246: Chirální flaviniové soli jako katalyzátory enantioselektivních sulfoxidací a N-oxidací</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Structure

ISSN

0022-2860

e-ISSN

—

Svazek periodika

1004

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

178-187

Kód UT WoS článku

000296927300024

EID výsledku v databázi Scopus

—