Prediction of Dissolution Behavior of Final Dosage forms Prepared by Different Granulation Methods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43894825" target="_blank" >RIV/60461373:22310/12:43894825 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62243136:_____/12:#0000285

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1877705812029463" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1877705812029463</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.proeng.2012.07.539" target="_blank" >10.1016/j.proeng.2012.07.539</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prediction of Dissolution Behavior of Final Dosage forms Prepared by Different Granulation Methods

Popis výsledku v původním jazyce

The release rate of an active pharmaceutical ingredient (API) from a dosage form, measured by a dissolution test, is one of the key parameters governing the formulation viability. A number of dissolution tests have to be performed during the life cycle of a dosage form. This number can be significantly reduced by prediction of the API dissolution behavior. Thus the aim of this work was to find if, and how precisely, it is possible to predict dissolution behavior of final dosage forms by carrying out theexperiments with their precursors. In this purpose the rate of release of a model API - caffeine -from a powdered, granulated and compacted form was observed. The experiments were performed in a flow-through cell dissolution apparatus (USP 4) with agglomerates and in a paddle dissolution apparatus (USP 2) with tablets and capsules. It was found that the caffeine release from the agglomerates was retarded by the excipient matrix and that compacted caffeine dissolved faster than granulate

Název v anglickém jazyce

Prediction of Dissolution Behavior of Final Dosage forms Prepared by Different Granulation Methods

Popis výsledku anglicky

The release rate of an active pharmaceutical ingredient (API) from a dosage form, measured by a dissolution test, is one of the key parameters governing the formulation viability. A number of dissolution tests have to be performed during the life cycle of a dosage form. This number can be significantly reduced by prediction of the API dissolution behavior. Thus the aim of this work was to find if, and how precisely, it is possible to predict dissolution behavior of final dosage forms by carrying out theexperiments with their precursors. In this purpose the rate of release of a model API - caffeine -from a powdered, granulated and compacted form was observed. The experiments were performed in a flow-through cell dissolution apparatus (USP 4) with agglomerates and in a paddle dissolution apparatus (USP 2) with tablets and capsules. It was found that the caffeine release from the agglomerates was retarded by the excipient matrix and that compacted caffeine dissolved faster than granulate

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0071" target="_blank" >ED2.1.00/03.0071: Unipetrol výzkumně vzdělávací centrum</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Procedia Engineering

ISSN

1877-7058

e-ISSN

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Svazek periodika

42

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

1463-1473

Kód UT WoS článku

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EID výsledku v databázi Scopus

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