Analysis of Drug Release from Different Agglomerates Using a Mathematical Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43898271" target="_blank" >RIV/60461373:22310/14:43898271 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.dissolutiontech.com/DTresour/201411Articles/DT201411_A04.pdf" target="_blank" >http://www.dissolutiontech.com/DTresour/201411Articles/DT201411_A04.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14227/DT210414P40" target="_blank" >10.14227/DT210414P40</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Drug Release from Different Agglomerates Using a Mathematical Model

Popis výsledku v původním jazyce

The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles.A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach,we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these e

Název v anglickém jazyce

Analysis of Drug Release from Different Agglomerates Using a Mathematical Model

Popis výsledku anglicky

The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles.A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach,we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these e

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dissolution Technologies

ISSN

1521-298X

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

40-47

Kód UT WoS článku

000347437200004

EID výsledku v databázi Scopus

—